@article {16147, title = {Enhancement of water solubility of poorly water-soluble drugs by new biocompatible N-acetyl amino acid N-alkyl cholinium-based ionic liquids}, journal = {Eur J Pharm Biopharm}, volume = {137}, year = {2019}, note = {

Jesus, Ana RSoromenho, Mario R C
Raposo, Luis R
Esperanca, Jose M S S
Baptista, Pedro V
Fernandes, Alexandra R
Reis, Patricia M
eng
Comparative Study
Netherlands
Eur J Pharm Biopharm. 2019 Apr;137:227-232. doi: 10.1016/j.ejpb.2019.03.004. Epub 2019 Mar 2.

}, month = {2019}, pages = {227-232}, abstract = {

The major challenge of the pharmaceutical industry is to find potential solvents for poorly water-soluble drug molecules. Ionic liquids (ILs) have attracted this industry as (co-) solvents due to their unique physicochemical and biological properties. Herein, a straightforward approach for the enhancement of the water solubility of paracetamol and sodium diclofenac is presented, using new biocompatible N-acetyl amino acid N-alkyl cholinium-based ionic liquids as co-solvents (0.2-1mol\%). These new ionic liquids were able to increase the water solubility of these drugs up to four times that in pure water or in an inorganic salt solution. In the presence of these ILs, the drugs lipophilicity (log P was not significantly changed for paracetamol, but for sodium diclofenac it was possible to decrease significantly its lipophilicity. Concerning cytotoxicity in human dermal fibroblasts it was observed that ILs did not show a significant toxicity, and were able to improve cell viability compared with the respective precursors.

}, keywords = {Acetaminophen/*chemistry/toxicity, Amino acids, Amino Acids/*chemistry, Bioavailability, Cell Survival/drug effects, Cells, Cultured, Chemistry, Pharmaceutical/methods, Choline/chemistry, cytotoxicity, Diclofenac/*chemistry/toxicity, Drug delivery, Fibroblasts/*drug effects/metabolism, Humans, Hydrophobic and Hydrophilic Interactions, ionic liquids, Ionic Liquids/chemistry, Solubility, Solvents/chemistry, Water/chemistry}, isbn = {1873-3441 (Electronic)0939-6411 (Linking) }, url = {https://www.ncbi.nlm.nih.gov/pubmed/30836180}, author = {Jesus, A. R. and Soromenho, M. R. C. and Raposo, L. R. and Esperanca, Jmss and P.V. Baptista and Fernandes, A. R. and Reis, P. M.} }