@article {12547,
	title = {Mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes as potential antiproliferative agents},
	volume = {175},
	year = {2017},
	note = {n/a},
	month = {2017},
	pages = {267 - 275},
	abstract = {<p>A series of four mixed ligand aroylhydrazone and N-donor heterocyclic Lewis base Cu(II) complexes [CuL(X)]2 [L refers to the dianionic form of (5-bromo-2-hydroxybenzylidene)-2-hydroxybenzohydrazide; X=pyrazine (Pz; 1), pyridine (Py; 2), imidazole (Imz; 3) and 3-pyridinecarbonitrile (3-PyCN; 4)] has been synthesized and characterized by elemental analysis, various spectroscopic techniques and X-ray crystallography (for 1, 2 and 4). The antiproliferative effect of complexes 1{\textendash}4 was examined in 4 human tumor cell lines (ovarian carcinoma (A2780), colorectal carcinoma (HCT116), lung adenocarcinoma (A549) and breast adenocarcinoma (MCF7)) and in normal human primary Fibroblasts. Complex 4 exhibits a high cytotoxic activity against ovarian and colorectal carcinoma cells (A2780, HCT116 respectively), with IC50 much lower than those for normal primary fibroblasts. Complex 4 could induce cell death via apoptosis but not autophagy in colorectal carcinoma cells.</p>
},
	keywords = {Antiproliferative agent, Aroylhydrazone ligand, Human tumor cell lines, Mixed ligand copper(II) complexes, X-ray Structure},
	isbn = {0162-0134},
	url = {http://www.sciencedirect.com/science/article/pii/S0162013417302635},
	author = {Manas Sutradhar and Rajeshwari, and Roy Barman, Tannistha and Alexandra R. Fernandes and Fabiana Paradinha and Catarina Roma-Rodrigues and Guedes da Silva, M. F{\'a}tima C. and Armando J. L. Pombeiro}
}
