@article {12543, title = {Targeting canine mammary tumours via gold nanoparticles functionalized with promising Co(II) and Zn(II) compounds}, journal = {Veterinary and Comparative Oncology}, volume = {15}, year = {2017}, note = {n/a}, month = {2017/12/01}, pages = {1537 - 1542}, publisher = {Blackwell Publishing Ltd}, abstract = {

Background: Despite continuous efforts, the treatment of canine cancer has still to deliver effective strategies. For example, traditional chemotherapy with doxorubicin and/or docetaxel does not significantly increase survival in dogs with canine mammary tumors (CMTs).Aims: Evaluate the efficiency of two metal compounds [Zn(DION)2]Cl (TS262, DION = 1,10-phenanthroline-5,6-dione) and [CoCl(H2O)(DION)2][BF4] (TS265) and novel nanovectorizations designed to improve the anti-cancer efficacy of these compounds in a new CMT derived cell line (FR37-CMT).
Materials and methods: FR37-CMT cells were exposed to different concentrations of TS262 and TS265 and two new nanoparticle systems and cellular viability was determined. These nanosystems are composed of polyethylene-glycol, bovine-serum-albumin and TS262 or TS265 (NanoTS262 or NanoTS265, respectively).
Results: In FR37-CMT, TS262 and TS265 displayed IC50 values well below those displayed by doxorubicin and cisplatin. The nanovectorizations further decreased the IC50 values.
Discussion: TS262 and TS265 proved to be effective against FR37-CMT cells and more effective than of doxorubicin and cisplatin. The Nanosystems efficiently delivered the cytotoxic cargo inducing a significant reduction of cell viability in FR37-CMT cell line when compared to the free compounds.
Conclusions: TS262 and TS265 are compounds with potential in the treatment of CMTs. NanoTS262 and NanoTS265 demonstrate that such simple nanovectorization via gold nanoparticles shows tremendous potential as anti-cancer formulations, which may easily be expanded to suit other cargo.

}, keywords = {1,10-phenanthroline-5,6-dione metal compounds, canine mammary tumours, cisplatin, Doxorubicin, FR37-CMT, Gold nanoparticles, nanotechnology}, isbn = {1476-5829}, url = {http://dx.doi.org/10.1111/vco.12298}, author = {Raposo, L. R. and Roma-Rodrigues, C. and J Jesus and Martins, L. M. D. R. S. and Pombeiro, A. J. and P.V. Baptista and Fernandes, A. R.} }