@article {8308,
	title = {The role of intramolecular interactions in the functional control of multiheme cytochromes c},
	journal = {FEBS Lett},
	volume = {586},
	year = {2012},
	pages = {504-509},
	abstract = {<p>Detailed thermodynamic and structural data measured in soluble monomeric multiheme cytochromes c provided the basis to investigate the functional significance of interactions between redox co-factors. The steep decay of intramolecular interactions with distance means that close proximity of the redox centers is necessary to modulate the intrinsic reduction potentials in a significant way. This ensures selection of specific populations during redox activity in addition to maintaining fast intramolecular electron transfer. Therefore, intramolecular interactions between redox co-factors play an important role in establishing the biological function of the protein by controlling how electrons flow through and are distributed among the co-factors.</p>
},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/21856299},
	author = {Fonseca, B.M. and Paquete, C.M. and Salgueiro, C.A. and Louro, R.O.}
}
