@article {13395,
	title = {Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release},
	journal = {Carbohydr Polym},
	volume = {153},
	year = {2016},
	pages = {212-221},
	abstract = {<p>In the present work composite nanoparticles with a magnetic core and a chitosan-based shell were produced as drug delivery systems for doxorubicin (DOX). The results show that composite nanoparticles with a hydrodynamic diameter within the nanometric range are able to encapsulate more DOX than polymeric nanoparticles alone corresponding also to a higher drug release. Moreover the synthesis method of the iron oxide nanoparticles influences the total amount of DOX released and a high content of iron oxide nanoparticles inhibits DOX release. The modelling of the experimental results revealed a release mechanism dominated by Fickian diffusion.</p>
},
	url = {https://doi.org/10.1016/j.carbpol.2016.07.109},
	author = {Soares, PIP and A. I. Sousa and Ferreira, IMM and Novo, CMM and Borges, J. P.}
}
