<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mara Soares da Silva</style></author><author><style face="normal" font="default" size="100%">Raquel Viveiros</style></author><author><style face="normal" font="default" size="100%">Patrícia I. Morgado</style></author><author><style face="normal" font="default" size="100%">Aguiar-Ricardo, Ana</style></author><author><style face="normal" font="default" size="100%">Correia, Ilídio J</style></author><author><style face="normal" font="default" size="100%">Casimiro, Teresa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Development of 2-(dimethylamino)ethyl methacrylate-based molecular recognition devices for controlled drug delivery using supercritical fluid technology</style></title><secondary-title><style face="normal" font="default" size="100%">International Journal of Pharmaceutics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">\{DMAEMA\}</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.sciencedirect.com/science/article/pii/S0378517311005357</style></url></web-urls></urls><number><style face="normal" font="default" size="100%">1</style></number><volume><style face="normal" font="default" size="100%">416</style></volume><pages><style face="normal" font="default" size="100%">61 - 68</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;This work reports the development of a novel potential body-friendly oral drug delivery system, which consists of a biocompatible molecularly imprinted polymer (MIP), with pH sensitive character and low cross-linking degree (20.2&amp;#xa0;wt%), synthesized and processed in supercritical carbon dioxide. The \{MIP\} is synthesized using 2-(dimethylamino)ethyl methacrylate (DMAEMA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker, and ibuprofen as molecular recognition template. The imprinted matrix was able to show a higher affinity towards ibuprofen than its corresponding non-imprinted polymer (NIP) meaning that the molecular imprinting in scCO2 was efficient even using a low crosslinking degree. \{MIP\} showed a significant molecular recognition towards the template, presenting higher drug uptake ability in the supercritical impregnation step, loading 33.1&amp;#xa0;wt% of ibuprofen compared to only 10.2&amp;#xa0;wt% for the \{NIP\} polymer. In vitro drug release experiments, simulating an oral administration, showed different release profiles at pH 2.2 and pH 7.4. Zeta potential measurements were performed to both \{MIP\} and \{NIP\} showing that the imprinting process has a significant influence on the charge of the polymeric particles. Cytotoxicity assays performed with human colorectal carcinoma-derived Caco-2 cells demonstrated that the polymers are biocompatible and could be potentially used in drug delivery applications.&lt;/p&gt;
</style></abstract><notes><style face="normal" font="default" size="100%">n/a</style></notes></record></records></xml>