@article {daSilva201161,
	title = {Development of 2-(dimethylamino)ethyl methacrylate-based molecular recognition devices for controlled drug delivery using supercritical fluid technology},
	journal = {International Journal of Pharmaceutics},
	volume = {416},
	number = {1},
	year = {2011},
	note = {n/a},
	pages = {61 - 68},
	abstract = {<p>This work reports the development of a novel potential body-friendly oral drug delivery system, which consists of a biocompatible molecularly imprinted polymer (MIP), with pH sensitive character and low cross-linking degree (20.2\&$\#$xa0;wt\%), synthesized and processed in supercritical carbon dioxide. The \{MIP\} is synthesized using 2-(dimethylamino)ethyl methacrylate (DMAEMA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker, and ibuprofen as molecular recognition template. The imprinted matrix was able to show a higher affinity towards ibuprofen than its corresponding non-imprinted polymer (NIP) meaning that the molecular imprinting in scCO2 was efficient even using a low crosslinking degree. \{MIP\} showed a significant molecular recognition towards the template, presenting higher drug uptake ability in the supercritical impregnation step, loading 33.1\&$\#$xa0;wt\% of ibuprofen compared to only 10.2\&$\#$xa0;wt\% for the \{NIP\} polymer. In vitro drug release experiments, simulating an oral administration, showed different release profiles at pH 2.2 and pH 7.4. Zeta potential measurements were performed to both \{MIP\} and \{NIP\} showing that the imprinting process has a significant influence on the charge of the polymeric particles. Cytotoxicity assays performed with human colorectal carcinoma-derived Caco-2 cells demonstrated that the polymers are biocompatible and could be potentially used in drug delivery applications.</p>
},
	keywords = {\{DMAEMA\}},
	issn = {0378-5173},
	doi = {http://dx.doi.org/10.1016/j.ijpharm.2011.06.004},
	url = {http://www.sciencedirect.com/science/article/pii/S0378517311005357},
	author = {Mara Soares da Silva and Raquel Viveiros and Patr{\'\i}cia I. Morgado and Aguiar-Ricardo, Ana and Correia, Il{\'\i}dio J and Casimiro, Teresa}
}
