<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paula I P Soares</style></author><author><style face="normal" font="default" size="100%">Sousa, Ana Isabel</style></author><author><style face="normal" font="default" size="100%">Ferreira, Isabel</style></author><author><style face="normal" font="default" size="100%">Novo, Carlos</style></author><author><style face="normal" font="default" size="100%">Borges, João Borges</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release</style></title><secondary-title><style face="normal" font="default" size="100%">Carbohydrate Polymers</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2016</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">10.1016/j.carbpol.2016.07.109</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">153</style></volume><pages><style face="normal" font="default" size="100%">212-221</style></pages><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify; font-size:12px; font-family:Helvetica&quot;&gt;In the present work composite nanoparticles with a magnetic core and a chitosan-based shell were produced as drug delivery systems for doxorubicin (DOX). The results show that composite nanoparticles with a hydrodynamic diameter within the nanometric range are able to encapsulate more DOX than polymeric nanoparticles alone corresponding also to a higher drug release. Moreover the synthesis method of the iron oxide nanoparticles influences the total amount of DOX released and a high content of iron oxide nanoparticles inhibits DOX release. The modelling of the experimental results revealed a release mechanism dominated by Fickian diffusion.&lt;/p&gt;
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