@article {2283,
	title = {DNA damage and metal accumulation in four tissues of feral Octopus vulgaris from two coastal areas in Portugal},
	journal = {Ecotoxicology and Environmental Safety},
	volume = {73},
	number = {7},
	year = {2010},
	note = {<p>Times Cited: 1</p>
},
	month = {Oct},
	pages = {1543-1547},
	abstract = {<p>The alkaline comet assay has been employed for the first time to estimate the basal DNA damage in the digestive gland, gills, kidney and gonads of Octopus vulgaris. Octopuses were captured in two coastal areas adjacent to the cities of Matosinhos (N) and Olhao (S), Portugal. The area of Matosinhos is influenced by discharges of the Douro River, city of Porto, industries and intensive agriculture, while Olhao is an important fisheries port. Previous works point to contrasting metal availability in the two coastal areas. Among the analysed tissues digestive gland presented the highest levels of Zn, Cu, Cd and Pb. Tissues of specimens from Matosinhos exhibited high levels of Cd and from Olhao enhanced Pb concentrations. The DNA damages in digestive gland, gills and kidney were more accentuated in specimens from Matosinhos than from Olhao, suggesting a stronger effect of contaminants. Elevated strand breakages were registered in digestive gland, recognised for its ability to store and detoxify accumulated metals. The DNA damages in kidney, gills and gonads were lower, reflecting reduced metal accumulation or efficient detoxification. The broad variability of damages in the three tissues may also mirror tissue function, specific defences to genotoxicants and cell-cycle turnover. (C) 2010 Elsevier Inc. All rights reserved.</p>
},
	isbn = {0147-6513},
	url = {http://dx.doi.org/10.1016/j.ecoenv.2010.07.034},
	author = {Raimundo, Joana and Costa, Pedro M. and Vale, Carlos and Costa, Maria Helena and Moura, Isabel}
}
