Financed Projects

National Projects (on-going):

PTDC/BBB-BEP/1185/2014

"Aldehyde Oxidases in Drug Metabolism and Biocatalysis: Searching for the Substrate Specificity and Catalytic Mechanism ",

PI:  Maria João Romão

PTDC/BBB-BEP/0869/2014

"B.EST.CBM: An integrative structural biology approach to characterise the protein-carbohydrate microbial recognition",

PI:  Ana Luísa Carvalho

PTDC/QEQ-MED/1902/2014

"Nanoagentes de monoxido de carbono COGSs para combater a Artrite Reumatoide",

PI:  Teresa Santos Silva

PTDC/IMI-MIC/1300/2014

"CtIncipedia – A multidisciplinary Chlamydia trachomatis inclusion membrane (Inc) proteins",

PI:  Jaime Mota

PTDC/BBB-EBB/2723/2014

"Reduction of CO2 for sustainable biofuel production",

PI:  Inês Cardoso Pereira

PTDC/BIA-MIC/5947/2014

"Molecular determinants of bacterial cellulosome diversity in different ecological niches",

PI:  Carlos Fontes

PTDC/DTP-FTO/1981/2014

"ACTONP53: Targeting p53 family proteins: on the route to new anticancer agents",

PI:  Lucília Saraiva

RECI/BBB-BEP/0124/2012

"Modern Structural Biology: Resources for the advancement of in-house X-ray crystallography",

PI:  Ana Luísa Carvalho

EXCL/QEQ-COM/0394/2012

"ENZYMATIC CATALYSIS - seeking a global picture", (FCUP and FCT/UNL)

PI:  Maria João Ramos

PTDC/BBB-BEP/3058/2012

"Ionic Liquid-based systems for protein crystallization", (ITQB and FCT/UNL)

PI:  Magdalena Kowacz

National Projects (finished):

EXPL/BBB-BQB/0750/2012

"Pylori GlycoArrays: Development of microarrays from Helicobacter pylori cell surface glycome toward immunological and serological studies",

PI:  Angelina de Sá Palma

EXPL/BBB-BEP/0506/2012

"Development of cohesin-microarrays for determining cohesin-dockerin specificities of novel cellulolytic species"

PI:  Benedita Pinheiro

PTDC/QUI-QUI/121752/2010

"Nitric Oxide Synthase and 99mTc/Re complexes bearing L-arginine derivatives: Structure-activity relationship", (ITN and FCT/UNL)

PI:  João Domingos Galamba Correia

PTDC/QUI-BIQ/117799/2010

“Protein interaction with CO Releasing Molecules (CORM)”,

PI: Teresa Santos-Silva

PTDC/BIA-PRO/118377/2010

“Mammalian and Bacterial Aldehyde Oxidases: Structure, mechanism and insights into cofactor binding and protein maturation”,

PI: Teresa Santos-Silva

PTDC/QUI-QUI/112537/2009

“A carbohydrate microarray platform for discovery of ligands in polysaccharides recognised by microbial carbohydrate-binding modules”,

PI: Maria Angelina Palma

PTDC/BIA-PRO/103980/2008

“Structure and function of novel Glycoside Hydrolases and Carbohydrate-Binding Modules of Clostridium thermocellum cellulosome”,

PI: Shabir Najmudin

PTDC/QUI-BIQ/100359/2008

"The Cellulosome assembly: structure, function and specificity of new cellulases and supramolecular complexes",

PI: Ana Luisa Carvalho

PTDC/QUI/64023/2006

“Production of a stable form of human phenylalanine hydroxylase: towards the 3D structure determination.” (FCT-UNL and FF-UL)

PI: Ana Paula Leandro

PTDC/QUI/64733/2006

“Xanthine Oxidase-Related Enzymes: Structure, Function and Specificity” (FCT-UNL),

PI: Maria João Romão

PTDC/QUI/64203/2006

“Structural and Functional Studies of the SOUL/HBP Family of Heme-binding Proteins” (UA and FCT-UNL),

PI: Brian James Goodfellow

PTDC/BIA-PRO/80486/2006

“Structural characterization of mRNA localization mechanisms” (FCT-UNL and Univ. Leeds, UK).

PI: José Trincão

POCTI/QUI/57641/2004

“Structural and Functional Characterization of Nitrate Reductases and Formate Dehydrogenases” (FCT-UNL),

PI: Maria João Romão.

POCTI/BIA-PRO/59118/2004

“Molecular determinants of ligand specificity in carbohydrate-binding modules and cohesin-dockerin complexes” (FMV-UTL and FCT-UNL)

PDCT/QUI/56985/2004

“Novo Tipo de Compostos Orientados para Receptores Biológicos com Potenciais Aplicações Farmacológicas” (IST and FCT-UNL)

POCI/QUI/55350/2004

“New molybdo and copper cofactors in proteins isolated from sulfate reducers” (FCT-UNL),

PI: Isabel Moura

POCTI/QUI74230972001

“Bacterial Cytochrome c Peroxidases-Activation, Enzymatic Mechanism and Structure”

POCTI/1999/BME/35078

“A crystallographic contribution to the understanding of the structure and function of Mo-enzymes”,

PI: Maria João Romão.

PRAXIS/C/BIA/11089/1998

“Molecular Biology and Structural Studies in Metalloproteins”

PTDC/BIA-PRO/69732/2006

“Estrutura e função de novos módulos de ligação a carbohidratos e complexos coesina-doquerina do Clostridium thermocellum” (FMV-UTL and FCT-UNL),

PI: Carlos Fontes

PTDC/QUI/68286/2006

“A combined approach of X-ray Crystallography, NMR and Computational Chemistry for the study of the molecular interactions that define the ligand specificity in cellulosomal Carbohydrate Binding Module” (FCT-UNL, FCUP and FMV-UTL),

PI: Ana Luísa Carvalho.

European Projects (finished):

2000/2003:

European Research Network TMR: (HPRN-CT-1999-00084) “The Mechanism, Specificity and Inhibition of Enzymes belonging to the Xantine Oxidase family: Medical and Industrial Applications.”, joint collaboration of eight European research groups.

1998/2002:

European Research Network TMR(FMRX-CT98-0204): “Structures and Reaction Mechanisms of Pteridine Related Enzymes”, collaboration among seven European research groups, including Industry (Zeneca Agrochemicals).

1996/1999:

BIOTECH”, (BIO4-CT96-0413) “Construction of Novel Redox Proteins from modular building blocks”. (six European laboratories).

1993/1996:

”HUMAN CAPITAL AND MOBILITY NETWORK”, (ERBCHXCT 930243) “Pteridines: Regulation, Biosynthesis and Pharmacology”. (eight European research groups).