Projects

Funded Projects and Prizes

  • aDVANCE Desenvolvimento de novas vacinas anticancro, QREN-ADI 2013-2015
  • Prémio de Inovação Bluepharma-Universidade de Coimbra 2014
  • Prémio de Mérito Científico Santander Totta – Universidade Nova de Lisboa 2012/2013
  • The role of sialic acid in the immunobiology of dendritic cells | PTDC/SAUMII/67561/2006 - Fundação para a Ciência e Tecnologia
  • Fulbright Commission to P. Videira (2013) and L. Rodrigues (2014)
  • Bolsa LPCC/PFIZER 2011 

Patents

National - Processo 108621 L, "A NOVEL DENDRITIC CELLS POPULATION, METHOD OF PRODUCTION AND USE THEREOF"

International - N/REF. PCT/IB2016/053901 WO 2017002045 A1 A VIABLE CELL POPULATION, METHOD FOR PRODUCTION AND USES THEREOF

Project details

Improved Dendritic cell-based vaccines for cancer treatment:

Aim: To identify the role of glycans expressed by human dendritic cells and use glycoengineering to improve dendritic cell based vaccines.

Glycans involved in haematogenous cell migration:

Aim: To identify the role of glycans expressed by human dendritic cells and cancer cells that contribute to transendothelial migration

Bispecific antibodies for breast cancer treatment:

Aim: To develop therapeutics to treat breast cancer that specifically target cancer cells, and simultaneously engage patient’s immune system to kill these tumor cells.



Host-pathogen interaction - In vitro model based on human dendritic cell functions:
Aim: to address mechanisms of immune evasion by bacteria
In vivo model of skin/ surgery infection  using immunocompetent rats:
Aim: to compare bacteria growth in skin or surgical wounds, to compare immune response after evasion, to test anti-microbial drugs and drug-delivery systems.
Aim
: To identify the role of glycans expressed by human dendritic cells and
use
glycoengineering to improve dendritic cell based vaccines.